| Title | Detection of cell-cyclic elements in mis-sampled gene expression data using a robust Capon estimator |
| Authors | Thomas Bowles, Andreas Jakobsson, Jonathon A. Chambers |
| Full-text | Available as PDF, Restricted Access |
| Publication | 2004 IEEE International Conference on Acoustics, Speech, and Signal Processing |
| Year | 2004 |
| Volume | 5 |
| Pages | 417 - 420 |
| Document type | Conference paper |
| Conference name | 2004 IEEE International Conference on Acoustics, Speech and Signal Processing |
| Conference Date | 2004-05-17 - 21 |
| Conference Location | Montreal |
| Status | Published |
| Quality controlled | Yes |
| Language | eng |
| Publisher | IEEE |
| Abstract English | We present a method for the estimation of possible cell-cyclic elements in mis-sampled microarray data. Accurate assessment of the frequency content of microarray data gives insight into genes which could be cell-cycle regulated. Cell-cycle regulation is one component of the complex network of genetic regulatory processes and is especially relevant to the study of cancer. As cDNA microarray experiments involve human sampling of cell populations, slight variations in the sampling times invariably occur. We propose estimating the frequency content of microarray data using the recent robust Capon estimator, and formulate a suitable uncertainty region over which to minimize. The estimator is shown to yield robust estimates with real microarray data and to identify cell-cyclic genes that elude both the traditional periodogram and the Capon spectral estimator |
| Keywords | cancer, cellular biophysics, DNA, estimation theory, genetics, parameter estimation, cell-cyclic elements detection, mis-sampled gene expression data, robust Capon estimator, frequency content, cell-cycle regulation, genetic regulatory processes, cDNA microarray experiments, minimization, eriodogram, Capon spectral estimator, |
| ISBN/ISSN/Other | ISBN: 0 7803 8484 9 |
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