| Title | On-demand vs. prophylactic treatment for severe haemophilia in Norway and Sweden: differences in treatment characteristics and outcome. |
| Authors | Katarina Steen Carlsson, Sören Höjgård, A. Glomstein, Stefan Lethagen, S. Schulman, Lilian Tengborn, Anna Lindgren, Erik Berntorp, Björn Lindgren |
| Full-text | Available as PDF |
| Alternative Location | http://dx.doi.org/10.1046/j..., Restricted Access |
| Publication | Haemophilia |
| Year | 2003 |
| Volume | 9 |
| Issue | 5 |
| Pages | 555 - 566 |
| Document type | Article |
| Status | Published |
| Quality controlled | Yes |
| Language | eng |
| Publisher | Blackwell Publishing |
| Abstract English | Using an 11-year panel of 156 Norwegian and Swedish patients with severe haemophilia, and including retrospective case-book data from birth, we compared the differences in the haemophilia-related resource use between on-demand and prophylactic treatment. Patients treated on-demand had more surgery (arthrodeses, prostheses implantations and synovectomies) and more days lost from work. Median annual factor-concentrate consumption among adults (18+) was 211 000 IU interquartile range (IQR) 154 000-268 000 or 3 024 IU kg-1 year-1 for patients on prophylactic treatment and 55 000 IU (IQR 28 000-91 000) for on-demand patients (780 IU kg-1 year-1). This was partly explained by the fact that the median dose per kg body weight was twice as great 28, (IQR 24-32) for prophylaxis compared with 14 (IQR 12-16) for on-demand. Prescribed dose per kg body weight was found to be an important factor explaining the variation in total annual factor-concentrate consumption per patient for both types of treatment. Other variables included in the panel-data regression analysis were the number of weeks on secondary prophylaxis for on-demand patients and age, body weight and type of haemophilia for children (0-17 years) on prophylaxis. Differences were consistently substantial and will affect both costs and benefits of the two treatment strategies. |
| ISBN/ISSN/Other | ISSN: 1351-8216 |
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