CANCERRISK HOS BARN TILL KVINNOR MED BRÖST-

          ELLER OVARIALCANCER; EN REGISTERSTUDIE

                      Anna Bladström


The purpose of this work is to estimate the incidence of
different cancer diseases for children with a mother who
has been diagnosed with breast or ovarial cancer. We have
also investigated if the cancer incidences depend on the
mother's age at diagnosis and if the incidence of breast
or ovarial cancer is higher if both mother and a sister
had cancer. Through the Swedish Cancer Registry, which was
established in 1958, all women before 1994 with a diagnosis
of breast or ovarial cancer were identified and about
160,000 potential mothers (index persons) were found.
Children born before 1961 were identified through the 1960
year census and children born from 1961 were found through
the Fertility Registry established this year. The identified
children constitute the study cohort and they were matched
against the Swedish Cancer Registry and the Population
Registry in order to get cancer cases and correct end of
follow-up. The offspring cohort was stratified according to
gender, age and calendar time and analysed by means of the
person-years method. Due to dependence between sibs we
developed a technique for dependent cohort data.