Berwin Turlach, Department of Statistics and Applied Probability, National University of Singapore Monotone penalised spline smoothing Abstract: Penalised spline smoothing (Eilers and Marx, 1996; Ruppert and Carroll, 2000) is, arguably, fast becoming the method of choice for non- and semiparametric regression models. The attractiveness of penalised spline smoothers is twofold. First, compared with other smoothing methods, e.g. smoothing splines or kernel smoother, fitting penalised splines smoothers is computationally less complex. Secondly, the connection between smoothing methods and mixed models (Speed, 1991) is particularly easy to establish for penalised spline smoothers. Thus, it is easy to incorporate a penalised spline smoother into a semiparametric regression model and fit the model using standard software available for fitting (linear) mixed models (Ruppert, Wand and Carroll, 2003). However, in some situations, one would like to combine the flexibility of nonparametric smoothing techniques with prior knowledge in the form of constraints on the response curve given by, say, a physical or economic theory. In this talk, we discuss how monotonicity constraints can be imposed on penalised spline smoothers.