Pär Johannesson, Fraunhofer-Chalmers Research Centre for Industrial Mathematics Variation Mode and Effect Analysis: A Case Study of an Air Engine Component Abstract We will present an application of the probabilistic branch of Variation Mode and Effect Analysis (VMEA) implemented as a first order, second moment reliability method. First order means that the failure function is approximated to be linear with respect to the main influencing variables, second moment means that only means and variances are taken into account in the statistical procedure. We study the fatigue life of an air engine component and aim at a safety margin that takes all scatter and uncertainties into account. Scatter is defined as random variation due to natural causes, such as non-homogeneous material, geometry variation within tolerances, load variation in usage, and other uncontrolled variation. Uncertainty is defined as unknown systematic errors, such as model errors in the numerical calculation of fatigue life, statistical errors in estimates of parameters, and unknown usage profile. By defining also uncertainties as random variables, the whole safety margin problem is put into a common framework of second order statistics, with the Gauss' approximation formula as the main tool. By using a simple log transformation, the failure function is regarded as linear enough for a proper estimate of the scatter and uncertainty contributions based on the first order approximation. Thus, the final estimated variance of the logarithmic life is obtained through summing the variance contributions of all sources of scatter and uncertainty, and it represents the total uncertainty in the life prediction. Motivated by the central limit theorem this logarithmic life random variable may be regarded as normally distributed, which gives possibilities to calculate relevant safety margins that, in turn, is transformed back to fatigue life margins for comparisons with demands.