Multiple Window Spectrum Analysis and some Applications Power density spectrum estimation methods can be divided into two main groups, non-parametric and parametric, where the periodogram belongs to the former. The spectrum is usually estimated by successively averaged periodograms or subspectra from time epochs which is almost non-overlapping. The subspectra are then assumed to be uncorrelated. Data is assumed to be stationary and is weighted with some window, e.g. Hanning, Blackman or Kaiser. To reduce the variance, Thomson has proposed the use of multiple windows. With certain constraints on data, e.g., locally white spectrum, the window-shapes are designed to give uncorrelated subspectra. However, it has been shown that for a varying spectrum, e.g., a spectrum that includes peaks, the performance of the Thomson multiple-window method deteriorates due to cross-correlation between the subspectra. For a predefined shape of a peaked spectrum the multiple windows can then be given as the Karhunen-Loéve basis functions to the corresponding covariance matrix to give uncorrelated spectra at the peak frequency. Two applications where the spectrum can be assumed to include peaks are the Electroencephalogram (EEG), which is the graphic representation of spontaneous electrical brain activity, and the Heart Rate Variability (HRV), the variation in the heart frequency. In both these applications transient non-stationary behaviour could be expected which calls for methods giving estimates with small variance as well as good time and frequency resolution.