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Current information Autumn 2009:

The course is unfortunately cancelled! Any student intending to take the course is welcome to take the course MASM21 Analysis of Survival data instead. Analysis of Survival Data starts Monday november 2, at 10:15-12.00 in MH:227. Analysis of Survival Data may be included in Biological and Medical Modelling on Engineering Mathematics instead of Statistics in Genetics.

Obsolete information Autumn 2007:

• Information in Swedish
  
• Visit at BMCs genotyping facilities on Tuesday December 4th at 13.15.
  We meet at the main entrance of BMC (Sölvegatan 19) at 13.10, then we will visit Johan Staaf in room BMCC13.
• An errata list for the course book (pdf) can be found here
  
  
• The course starts with an introductory lecture
  Monday October 22nd 2007 at 10:15-12:00 in MH:329
• Course occations: 22/10 -- 5/12, Tuesdays 8.15-10.00 and Thursdays 10.15-12.00
  

Teacher:

Linda Hartman, tel 046-222 47 79, linda@maths.lth.se, MH:138A.

Prerequisites:

A basic course in mathematical statistics and an additional course in stochastic processes. Conditional probabilities are improtant for the course.

Course contents:

The course covers methods for using statistical methods in gene mapping for human hereditary diseases, i.e. localising corresponding chromosome positions in the human genome. Initially, an introduction to statistical genetics is presented, including genetical definitions. Secondly, theory and methodology within the fields of parametric- and nonparametric linkage analysis and association analysis are discussed.

The course is a är "sistercourse" to BNF073: Statistics in Genetics at the Bioinformatics Master programme.

Course schedule:

The course schedule (preliminary version) [pdf][ps]

General information:

A pigeon-hole for the course is located on the first floor of Matematikhuset, entrance Mathematical statistics, just to the right above the stairs. Mathematical statistics has a notice-board at the ground floor, left of the entrances in the lobby.

Examination:

Home exam, compulsory computer exercises, and oral project presentation. The course grade is based 90% on the home exam and 10% on the project presentation.

Computer laboration/Project:

Compulsory moments: Attend and participate in the final seminar where the course participants presents their individual projects (carried out in groups od two students)

For the linkage lab, we use the analysis program GENEHUNTER, and for association analysis we use Haploview.

Teaching:

The course instruction is through cooperative learning.

Kurslitteratur:

• Ziegler, A. & König, I. A Statistical Approach to Genetic Epidemiology Wiley-VCH 2006,
  ISBN-13: 978-3-527-31252-8
An errata list (pdf) can be found here

Övrigt:

• Guide for the computer lab etc. will be found at Course material.
• Relaterad Litteratur:
  
  
  • Compendium: Almgren, P., Bendahl, P.O., Bengtsson, H., Hössjer, O. & Perfekt, R. Statistics in Genetics (Version: 25 november 2003). Sold for 150 SEK by Aurelia Vogel, Matematical statistics.
    
  • Haines, J.L. & Pericak-Vance, M.A. Genetic Analysis of Complex Disease. 2nd ed. Wiley-Liss, New York, 2006.
    
  • Lynch, J. & Walsh, B. Genetics and Analysis of Quantitative Traits. Sinaure Associates Inc., Sunderland, MA, 1998.
    
  • Ott, J. Analysis of Human Genetic Linkage. 3rd ed. Johns Hopkins University Press, Baltimore, 1999.
    
  • Sham, P. Statistics in Human Genetics. Arnold Applications of Statistics, New York, 1998.
    
  • Strachan, T. & Read, A. Human Molecular Genetics. 3rd ed. Taylor & Francis Inc, UK, 2003.
    
  • Terwilliger, J.D. & Ott, J. Handbook of Human Genetic Linkage. Johns Hopkins University Press, Baltimore, 1994.
    
  • Thomas, D.C. Statistical Methods in Genetic Epidemiology. Oxford University Press, New York, 2004.
    
  
  
• May not be included in your degree together with the course BNF073: Statistics in Genetics.